This is a thoroughly researched gene. One polymorphism, in particular, has been extensively researched in association with various mental and emotional conditions. This article explains the basics and summarises the research. Which polymorphisms are we talking about? Genetic Genie reports on the following polymorphisms: COMT V158M   rs4680  (also called Val/Met and Met/Met)  COMT H62H … More The COMT polymorphism